Meaning has remained one of the contentious notions in the traditions of human sciences. In literature, literary theory and criticism the concept of meaning and meaninglessness has been variously addressed. The question of whether it should be desirable to seek meaning in works of Art or Literature or not has also seen its days of prominence and descent. The focal point to grasp meaning has also shifted from author to text to reader’s consciousness. The application of linguistic model has given us Structuralism and Post-Structuralism which in turn suggest that meaning is fundamentally a slippery issue because of the inherent system of language. In the problematic genre of Postmodernism, in which Salman Rushdie’s works are often counted, the discussion around the idea of meaning is central. Rushdie’s Midnight’s Children is one of the most important novels of twentieth century. The novel contains an ensemble of themes – Post-colonialism, Identity, Nationality, Religion, Sex, Gender etc. Overall it is a cacophony of remanence, an accumulation of so much history and events. Against the backdrop of this novel, the issue of meaning, as articulated through the protagonist Saleem Sinai, and its tension with the contemporary notion of meaning in Postmodernist framework will be addressed.